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To facilitate your μMap research, we offer kits containing all the chemical reagents you need to prepare your antibody conjugated photo probes.
To facilitate your μMap research, we offer kits containing all the chemical reagents you need to prepare your antibody conjugated photo probes.
To develop drugs that target a specific cell surface protein, it's helpful to know which other proteins reside in its vicinity. Geri et al. report a light-triggered labeling technique that improves the spatial resolution for this type of mapping. Specifically, they rely on a photocatalyst with a very short energy-transfer range to activate a carbene-based label that can only diffuse a short ...
The breakthrough technology, named µMap by the team of Princeton researchers and Merck scientists, uses a photocatalyst — a molecule that, when activated by light, spurs a chemical reaction — to identify spatial relationships on cell surfaces. The catalyst generates a marker that tags proteins and their molecular neighbors, which in turn enables the precise mapping of their micro-environment.
MacMillan illuminates the micro-environment, creating a new path to cancer drugs Princeton University's Dave MacMillan led the effort to create a nanoscale map of proteins and their nearest neighbors.
Merck and Princeton scientists create method to map cell-surface microenvironments
Merck and Princeton scientists create method to map cell-surface microenvironments
The technique, called MicroMapping, identifies potential protein interactions on and between cells
by Ryan Cross C&E news MARCH 11, 2020 | APPEARED IN VOLUME 98, ISSUE 10
Highlighted in the 2020 list of top new technologies by Chemistry and Engineering News
Highlighted in the 2020 list of top new technologies by Chemistry and Engineering News
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