Many disease pathologies can be understood through the elucidation of localized biomolecular networks, or microenvironments. To this end, enzymatic proximity labeling platforms are broadly applied for mapping the wider spatial relationships in subcellular architectures. In a recent publication, a revolutionary microenvironment mapping platform was described. This allows for the selective identification of protein-protein interactions on cell membranes with substantially higher levels of precision than currently available technologies. Using this photocatalyst-antibody conjugate to spatially localize carbene generation, selective labeling of antibody binding targets and their microenvironment protein neighbors is possible.